Altai Protocol Library

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Kütüphanede Ara Ara

New Protocol: Ivosidenib + chemotherapy for IDH-mutated AML

New Protocol: Ivosidenib + chemotherapy for IDH-mutated AML
Study:
  • Phase I, multi-center, open-label study
  • Newly diagnosed acute myeloid leukemia with mutated IDH1 or IDH2
  • Continuous ivosidenib (mIDH1) or enasidenib (mIDH2) with induction 7 + 3 chemo
Efficacy:
  • CR: 77% in mIDH1 & 74% in mIDH2
  • Treatment failure: 13% in mIDH1 & 13% in mIDH2
  • IDH mutation clearance: 39% in mIDH1 % 23% in mIDH2
  • OS @ 1 yr: 78% in mIDH1 & 76% in mIDH2
Safety:
  • Grade >=3 non-heme AEs: QT prolongation (10% ivosidenib & 8% enasidenib), elevated bilirubin (7% ivosidenib & 16% enasidenib), rash (5% & 14%)

Blood. 2021;137(13):1792-1803

Stein EM, et al. Ivosidenib or enasidenib combined with intensivechemotherapy in patients with newly diagnosed AML:a phase 1 study

https://doi.org/10.1182/blood.2020007233

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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