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New Protocol: Panitumumab + FU/FA for maintenance in colorectal cancer

New Protocol: Panitumumab + FU/FA for maintenance in colorectal cancer
Study:
  • Open-label randomized trial (AIO KRK 0212)
  • RAS Wild-type metastatic colorectal cancer
  • Post first-line induction therapy with six cycles of FU/FA and oxaliplatin plus Pmab
  • FU/FA plus Pmab or FU/FA
Efficacy:
  • PFS: 8.8 vs 5.7 months (HR, 0.72; 80% CI, 0.60 to 0.85; P = .014)
  • OS: 28.7 vs 25.7 months (HR, 0.84; 95% CI, 0.60 to 1.18; P = .32)
  • ORR: 40.8% vs 26% (OR, 1.96; 95% CI, 1.14 to 3.36; P= .02)
Safety:
  • Grade >=3 AEs: All 43.2% vs 26%,
  • Serious grade 3-4 AE:12.8% vs 10.6%, skin rash 7.2% vs 0

J Clin Oncol. 2022;40(1):72-82.

Modest DP, et al. Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212)

https://doi.org/10.1200/JCO.21.01332

Reviewed by Cagri Yildirim, MD on Sep 30, 2021

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