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Altai Protocol Library

New Protocol: Polatuzumab-R-CHP for DLBCL

New Protocol: Polatuzumab-R-CHP for DLBCL
Study:
  • Double-blind Phase III trial
  • Untreated intermediate-risk or high-risk DLBCL
  • Polatuzumab-R-CHP vs R-CHOP
Efficacy:
  • 2 years PFS: 76.7% vs 70.2% (HR:0.73 95% Cl 0.57-0.95 p=0.02)
  • 2 years OS: 88.7% vs 88.6% (HR:0.94 95% Cl 0.65-1.37 p=0.75)
Safety:
  • Any grades AEs: All 97.9% vs 98.4%,
  • Grade >=3 AEs: 60.7% vs 59.8%
  • Serious AEs:34.0% vs 30.6%
  • Grade 5 AEs: 3.0% vs 2.3%

N Engl J Med. 2022;386:351-63.

Tilly H, et al. Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma

https://doi.org/10.1056/NEJMoa2115304

Reviewed by Hasan Cagri Yildirim, MD on Sep 30, 2021

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