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Altai Protocol Library

New Protocol: R-CHOP + Lenalidomide (R2-CHOP) for previously untreated ABC-type DLBCL

New Protocol: R-CHOP + Lenalidomide (R2-CHOP) for previously untreated ABC-type DLBCL
Study:
  • Randomized, double-blind phase III trial (ROBUST)
  • Previously untreated ABC-type diffuse large B cell lymphoma
  • CD20+, Stages II-IV, cell of origin identified using nCounter Dx
  • R-CHOP + lenalidomide x 6 (n=285) vs. R-CHOP x 6 (n=285)
Efficacy:
  • CR: 69% vs. 65% (NS)
  • PFS @ 2yr: 67% vs. 64% (NS)
  • OS @ 2yr: 79% vs. 80% (NS)
Safety:
  • Grade >=3 AEs: neutropenia (60% vs. 48%), febrile neutropenia (14% vs. 9%), thrombocytopenia (17% vs. 11%), DVT (<1% vs. <1%)

J Clin Oncol. 2021 Feb 23.

Nowakowski GS, et al. ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

https://doi.org/10.1200/JCO.20.01366

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