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New Protocol: R-CHOP + Lenalidomide (R2-CHOP) for previously untreated ABC-type DLBCL

New Protocol: R-CHOP + Lenalidomide (R2-CHOP) for previously untreated ABC-type DLBCL
Study:
  • Randomized, double-blind phase III trial (ROBUST)
  • Previously untreated ABC-type diffuse large B cell lymphoma
  • CD20+, Stages II-IV, cell of origin identified using nCounter Dx
  • R-CHOP + lenalidomide x 6 (n=285) vs. R-CHOP x 6 (n=285)
Efficacy:
  • CR: 69% vs. 65% (NS)
  • PFS @ 2yr: 67% vs. 64% (NS)
  • OS @ 2yr: 79% vs. 80% (NS)
Safety:
  • Grade >=3 AEs: neutropenia (60% vs. 48%), febrile neutropenia (14% vs. 9%), thrombocytopenia (17% vs. 11%), DVT (<1% vs. <1%)

J Clin Oncol. 2021 Feb 23.

Nowakowski GS, et al. ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

https://doi.org/10.1200/JCO.20.01366

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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