Altai Protocol Library

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Kütüphanede Ara Ara

New Protocol: Romidepsin and oral azacytidine for PTCL

New Protocol: Romidepsin and oral azacytidine for PTCL
Study:
  • Multi-center, phase II study
  • Treatment-naïve (n= 10) or relapsed/refractory (n=13) peripheral T-cell lymphoma
  • Oral azacytidine 300 daily (d1-14) + romidepsin IV on days 8,15,22 (35 day cycle)
Efficacy:
  • CR: 50% in treatment-naïve & 38% in RR
  • ORR: 70% in treatment-naïve & 54% in RR
Safety:
  • Grade >=3 AEs: Thrombocytopenia (48%), neutropenia (40%), lymphopenia (32%), anemia (16%), febrile neutropenia (12%), nausea (8%), hyperbilirubinemia (8%)

Blood. 2021 Apr 22;137(16):2161-2170

Falchi L, et al. Combined Oral 5-Azacytidine and Romidepsin are Highly Effective in Patients withPTCL: A Multicenter Phase 2 Study

https://doi.org/10.1182/blood.2020009004

Altai Chemo Planner

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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