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Kütüphanede Ara Ara
Altai Protocol Library

New Protocol: Romidepsin and oral azacytidine for PTCL

New Protocol: Romidepsin and oral azacytidine for PTCL
Study:
  • Multi-center, phase II study
  • Treatment-naïve (n= 10) or relapsed/refractory (n=13) peripheral T-cell lymphoma
  • Oral azacytidine 300 daily (d1-14) + romidepsin IV on days 8,15,22 (35 day cycle)
Efficacy:
  • CR: 50% in treatment-naïve & 38% in RR
  • ORR: 70% in treatment-naïve & 54% in RR
Safety:
  • Grade >=3 AEs: Thrombocytopenia (48%), neutropenia (40%), lymphopenia (32%), anemia (16%), febrile neutropenia (12%), nausea (8%), hyperbilirubinemia (8%)

Blood. 2021 Apr 22;137(16):2161-2170

Falchi L, et al. Combined Oral 5-Azacytidine and Romidepsin are Highly Effective in Patients withPTCL: A Multicenter Phase 2 Study

https://doi.org/10.1182/blood.2020009004

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