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New Protocol: Selinexor – bortezomib – dexamethasone for previously treated myeloma

New Protocol: Selinexor – bortezomib – dexamethasone for previously treated myeloma

Open-label, phase 3 trial (BOSTON)
Multiple myeloma progressed on or after last treatment regimen, previously received 1-3 regimens
Selinexor – wkly bortezomib – dexamethasone (n=195) vs. twice wkly bortezomib – dexamethasone (n=207)
ORR: 76.4% vs. 62.3% (p=0.0012)
Median DoR: 20.3 vs. 12.9 mos (HR: 0.81 [0.56-1.17])
Median PFS: 13.9 vs. 9.5 mos (HR: 0.70 [0.53-0.93])
Grade 3-4 AEs: Thrombocytopenia (39% vs. 17%), neutropenia (9% vs. 3%), pneumonia (12% vs. 10%), fatigue (13% vs. 1%), nausea (8% vs. 0), diarrhea (6% vs. 1%)

Lancet 2020; 396: 1563–73
Grosicki S, et al. Once-per-week selinexor, bortezomib, and dexamethasone
versus twice-per-week bortezomib and dexamethasone in
patients with multiple myeloma (BOSTON): a randomised,
open-label, phase 3 trial.

https://doi.org/10.1016/S0140-6736(20)32292-3

Reviewed by Ulas Darda Bayraktar, MD on Dec 22, 2020

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