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New Protocol: Selinexor/daratumumab/dexamethasone for relapsed/refractory multiple myeloma

New Protocol: Selinexor/daratumumab/dexamethasone for relapsed/refractory multiple myeloma
Study:
  • Part of open-label Phase I/IIb STOMP – dose escalation and expansion phases
  • MM with >= 3 prior lines of therapy (to include PI and IMiD)
  • Selinexor: Once wkly 100 mg (n=31) and twice wkly 60 mg (n=3) + daratumumab + dex
Efficacy:
  • ORR: 69% (overall), 69% (bortezomib & lenalidomide refractory pts)
  • Two pts with daratumumab-refractory disease had not responded
  • All responses within first cycle
  • Median DoR: 11.4 mos [9.7 mos – NE]
Safety:
  • Grade 3-4 AEs: Neutropenia (27%), thrombocytopenia (47%), anemia (32%), fatigue (18%), hyponatremia (12%), nausea (9%), diarrhea (3%), infusion-related reaction (3%)

eJHaem. 2021;2:56–65.

Gasparetto C, et al. Selinexor, daratumumab, and dexamethasone in patients with

relapsed or refractory multiple myeloma

https://doi.org/10.1002/jha2.122

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