Altai Protocol Library

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Kütüphanede Ara Ara

New Protocol: Selinexor/pomalidomide/dexamethasone for relapsed/refractory multiple myeloma

New Protocol: Selinexor/pomalidomide/dexamethasone for relapsed/refractory multiple myeloma
Study:
  • Part of open-label Phase I/IIb STOMP – dose escalation and expansion phases
  • MM with >= 3 prior lines of therapy (to include PI and IMiD)
  • Selinexor (SEL) and pomalidomide (POM) dose escalated
Efficacy:
  • POM-naïve pts (n=33) => ORR: 58%, median PFS: 12.3 mos
  • Pts with previous POM (n=14): ORR: 36%, median PFS: 8.8 mos
Safety:
  • Grade 3-4 AEs: Neutropenia (56%), thrombocytopenia (35%), anemia (37%), fatigue (12%), nausea (2%)
  • Recommended phase II dose is SEL 60 mg PO wkly + POM 4 mg PO daily (21/28 d) + dexamethasone 40 mg wkly

Blood (2020) 136 (Supplement 1): 18–19

Chen CI, et al. Selinexor in Combination with Pomalidomide and Dexamethasone (SPd) for Treatment of Patients with Relapsed Refractory Multiple Myeloma (RRMM)

https://doi.org/10.1182/blood-2020-139858

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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