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New Protocol: SubQ daratumumab – carfilzomib – dexamethasone for myeloma

New Protocol: SubQ daratumumab – carfilzomib – dexamethasone for myeloma
Study:
  • Single arm cohort study
  • Relapsed or refractory multiple myeloma
  • Prior 1 to 3 lines therapy
  • Daratumumab 1800 mg SC, hyaluronidase 30000 units SC, carfilzomib IV and dexamethasone peroral
Efficacy:
  • ORR: 84.8% (95% CI, 73.9%-92.5%)
  • Stringent CR: 16.7%, CR:21.2%, very good partial response: 39.4
  • Ongoing response>=6 months: 85.2% (95% CI, 72.5%-92.3) and >=9 months: 82.5% (95% CI, 68.9%-90.6%)
Safety:
  • All grade AE: upper respiratory tract infection: 52%, fatigue:39%, insomnia 33%

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-darzalex-faspro-kyprolis-and-dexamethasone-multiple-myeloma

Reviewed by Hasan Cagri Yildirim, MD on Sep 30, 2021

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