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New Protocol: subQ daratumumab + CyBorD in light chain amyloidosis

New Protocol: subQ daratumumab + CyBorD in light chain amyloidosis

• Open-label, randomized phase III trial (ANDROMEDA)
• Newly diagnosed light chain amyloidosis with >=1 affected organ
• CyBorD with or without subQ daratumumab (n= 195 and 193, respectively)
• Hematologic CR: 42% vs. 13% (p<0.0001)
• HR for Organ deterioration PFS: 0/58 [0.37-0.92]

Not published as of Feb 6, 2021. Based on package insert
https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/761145s002lbl.pdf

Reviewed by Ulas Darda Bayraktar, MD on Feb 6, 2021

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