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New Protocol: subQ daratumumab + CyBorD in light chain amyloidosis

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New Protocol: subQ daratumumab + CyBorD in light chain amyloidosis
Study:
  • Open-label, randomized phase III trial (ANDROMEDA)
  • Newly diagnosed light chain amyloidosis with >=1 affected organ
  • CyBorD with or without subQ daratumumab (n= 195 and 193, respectively)
Efficacy:
  • Hematologic CR: 42% vs. 13% (p<0.0001)
  • HR for Organ deterioration PFS: 0/58 [0.37-0.92]

Not published as of Feb 6, 2021. Based on package insert

https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/761145s002lbl.pdf

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