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New protocol: SubQ daratumumab + pomalidomide + dexamethasone for relapsed/refractory multiple myeloma

New protocol: SubQ daratumumab + pomalidomide + dexamethasone for relapsed/refractory multiple myeloma
Study:
  • Open-label phase 3 trial. Relapsed/refractory MM patients who received >=1 prior line of therapy
  • Daratumumab subQ (1800 mg q1-2 wk) + Pomalidomide + dexamethasone (n=151) vs. Pd alone (n=153)
Efficacy:
  • >=VGPR: 51.0% vs. 19.6%
  • >=CR: 24.5% vs. 3.9%
  • Median PFS: 12.4 mos vs. 6.9 mos. HR for PFS = 0.63 [0.47 – 0.85]
Safety:
  • Grade >=3 adverse events: Neutropenia (68% vs. 51%), lymphopenia (12% vs. 3%), febrile neutropenia (9% vs. 3%), pneumonia (13% vs. 7%)

Presented at: 2021 ASH Annual Meeting; December 4, 2020. Abstract 412.

Dimopoulos MA, et al. Apollo: Phase 3 Randomized Study of Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) Versus Pomalidomide and Dexamethasone (Pd) Alone in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM).

https://ash.confex.com/ash/2020/webprogram/Paper135874.html

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