Altai Protocol Library

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Altai Protocol Library December 7, 2020

New protocol: SubQ daratumumab + pomalidomide + dexamethasone for relapsed/refractory multiple myeloma

New protocol: SubQ daratumumab + pomalidomide + dexamethasone for relapsed/refractory multiple myeloma
Open-label phase 3 trial. Relapsed/refractory MM patients who received >=1 prior line of therapy Daratumumab subQ (1800 mg q1-2 wk) + Pomalidomide + dexamethasone (n=151) vs. Pd alone (n=153) >=VGPR: 51.0% vs. 19.6% >=CR: 24.5% vs. 3.9% Median PFS: 12.4 mos vs. 6.9 mos. HR for PFS = 0.63 [0.47 – 0.85] Grade >=3 adverse events: Neutropenia (68% vs. 51%), lymphopenia (12% vs. 3%), febrile neutropenia (9% vs. 3%), pneumonia (13% vs. 7%)
Presented at: 2021 ASH Annual Meeting; December 4, 2020. Abstract 412. Dimopoulos MA, et al. Apollo: Phase 3 Randomized Study of Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) Versus Pomalidomide and Dexamethasone (Pd) Alone in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM). https://ash.confex.com/ash/2020/webprogram/Paper135874.html
Reviewed by Ulas Darda Bayraktar, MD on Dec 7, 2020

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.