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New Protocol: Trastuzumab Combined with Ramucirumab and Paclitaxel in Patients with Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Advanced Gastric or Gastroesophageal Junction Cancer

New Protocol: Trastuzumab Combined with Ramucirumab and Paclitaxel in Patients with Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Advanced Gastric or Gastroesophageal Junction Cancer
Study:
  • Open-label, multicenter, phase Ib/II trial
  • HER2-positive advanced G/GEJ cancer that progressed from trastuzumab-containing first-line chemotherapy with fluoropyrimidine and platinum
Efficacy:
  • cORR: 54.0% [27 of 50 pts]
  • mPFS: 7.1 mos [4.8-9.4]
  • mOS: 13.6 mos [9.4-17.7]
  • DoR: 6.7 mos [1.5-11.9]
Safety:
  • Grade≥3: Neutropenia (52%), anemia (8%)

J Clin Oncol JUN 26, 2023

Kim Gon Chang et al. Trastuzumab Combined With Ramucirumab and Paclitaxel in Patients With Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Advanced Gastric or Gastroesophageal Junction Cancer

http://doi.org/10.1200/JCO.22.02122

Reviewed by Elvin CHALABİYEV, MD on JUL 10, 2023

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