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New Protocol: Trastuzumab deruxtecan for her2+ metastatic colorectal cancer

New Protocol: Trastuzumab deruxtecan for her2+ metastatic colorectal cancer
Study:
  • Open-label phase II trial (DESTINY-CRC01)
  • Her2 overexpressing metastatic colorectal cancer that progressed on >=2 regimens
  • Cohort A: IHC 3+ or ISH-positive (n=53) analyzed
  • Trastuzumab deruxtecan 6.4 mg/kg IV q21d
Efficacy:
  • CR: 2%, ORR: 45%
  • Median PFS: 4.1 mos
  • Median OS: 5.4 mos
Safety:
  • Grade >=3 AEs: neutropenia (21%), anemia (14%), nausea (6%)

Lancet Oncol. Published Online. May 4, 2021

Siena S, et al. Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial

https://doi.org/10.1016/S1470-2045(21)00186-8

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