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New Protocol: Trastuzumab deruxtecan for her2-positive gastric cancer

New Protocol: Trastuzumab deruxtecan for her2-positive gastric cancer

• Open-label, randomized phase II trial (DESTINY-Gastric01)
• Her2-positive gastric/GE junction adenoCa pts who received >=2 previous regimens including 5-FU, platinum, and trastuzumab
• Trastuzumab deruxtecan (n= 125) vs. physician’s choice of irinotecan or PACLitaxel (n=62)
• Confirmed response: 43% [34% – 52%] vs. 12% [5% – 24%]
• Median duration of confirmed response: 11.3 mos [5.6 mos – NE] vs. 3.9 mos [3.0 – 4.9 mos]
• OS: 12.5 mos vs. 8.4 mos (HR: 0.59 [0.39 – 0.88])
• Grade 3-4 AEs: Neutropenia (51% vs. 24%), anemia (38% vs. 23%), thrombocytopenia (12% vs. 4%)

N Engl J Med 2020;382:2419.
Shitara K, et al. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer
https://doi.org/10.1056/NEJMoa2004413

Reviewed by Ulas Darda Bayraktar, MD on Feb 6, 2021

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