Altai Protocol Library

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Kütüphanede Ara Ara

New Protocol: Trastuzumab deruxtecan for her2-positive gastric cancer

New Protocol: Trastuzumab deruxtecan for her2-positive gastric cancer
Study:
  • Open-label, randomized phase II trial (DESTINY-Gastric01)
  • Her2-positive gastric/GE junction adenoCa pts who received >=2 previous regimens including 5-FU, platinum, and trastuzumab
  • Trastuzumab deruxtecan (n= 125) vs. physician’s choice of irinotecan or PACLitaxel (n=62)
Efficacy:
  • Confirmed response: 43% [34% – 52%] vs. 12% [5% – 24%]
  • Median duration of confirmed response: 11.3 mos [5.6 mos – NE] vs. 3.9 mos [3.0 – 4.9 mos]
  • OS: 12.5 mos vs. 8.4 mos (HR: 0.59 [0.39 – 0.88])
Safety:
  • Grade 3-4 AEs: Neutropenia (51% vs. 24%), anemia (38% vs. 23%), thrombocytopenia (12% vs. 4%)

N Engl J Med 2020;382:2419.

Shitara K, et al. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer

https://doi.org/10.1056/NEJMoa2004413

Altai Chemo Planner

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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