Altai Protocol Library

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Kütüphanede Ara Ara

New Protocol: Vemurafenib + riTUXimab for hairy cell leukemia

New Protocol: Vemurafenib + riTUXimab for hairy cell leukemia
Study:
  • Phase II single-center trial (HCL-PG03)
  • Refractory or relapsed hairy cell leukemia with b-raf V600E mutation
  • Total of 18 wks of therapy including vemurafenib 960 mg BID x 8 wks and eight IV riTUXimab infusions (n=31)
Efficacy:
  • CR: 87%
  • PFS @ 37 mos: 78%
  • RFS @ 34 mos: 85%
  • Absence of previous exposure to b-raf inhibitors and occurrence of MRD negativity associated with improved RFS (post-hoc)
Safety:
  • Grade >=3 AEs: neutropenia (13%), hyperbilirubinemia (19%), elevated pancreatic enzymes (29%), hypophosphatemia (10%), elevated ALKP or GGT (6%), anemia (3%)

N Engl J Med 2021; 384:1810-23

Tiacci E, et al. Vemurafenib plus Rituximab in Refractory or Relapsed Hairy-Cell Leukemia

https://doi.org/10.1056/NEJMoa2031298

Altai Chemo Planner

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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