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New Protocol: Vemurafenib + riTUXimab for hairy cell leukemia

New Protocol: Vemurafenib + riTUXimab for hairy cell leukemia
  • Phase II single-center trial (HCL-PG03)
  • Refractory or relapsed hairy cell leukemia with b-raf V600E mutation
  • Total of 18 wks of therapy including vemurafenib 960 mg BID x 8 wks and eight IV riTUXimab infusions (n=31)
  • CR: 87%
  • PFS @ 37 mos: 78%
  • RFS @ 34 mos: 85%
  • Absence of previous exposure to b-raf inhibitors and occurrence of MRD negativity associated with improved RFS (post-hoc)
  • Grade >=3 AEs: neutropenia (13%), hyperbilirubinemia (19%), elevated pancreatic enzymes (29%), hypophosphatemia (10%), elevated ALKP or GGT (6%), anemia (3%)

N Engl J Med 2021; 384:1810-23

Tiacci E, et al. Vemurafenib plus Rituximab in Refractory or Relapsed Hairy-Cell Leukemia

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