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Altai Protocol Library December 23, 2020

New Protocol: Venetoclax Added to Cladribine + Cytarabine alternating with Azacytidine for newly diagnosed AML in Elderly

New Protocol: Venetoclax Added to Cladribine + Cytarabine alternating with Azacytidine for newly diagnosed AML in Elderly
Phase II trial – Newly diagnosed AML (excluding APL, CBF) in pts >= 60 yrs Induction with Cladribine + low-dose subQ cytarabine x 1-2 cycles + Venetoclax Consolidation with cladribine + low-dose subQ cytarabine x 2 cycles alternating with azacytidine x 2 cycles, all cycles combined with venetoclax (21/28d), max 18 cycles (n=48) CR/CRi: 94% Median RFS: NR, 12-month RFS: 64% Median OS: NR, 12-month OS: 70% Grade >=3 non-heme AEs: Neutropenic fever (42%), lung infection (19%)
Presented at: 62nd ASH Annual Meeting; December 5, 2020. Abstract 616. Kadia TM, et al. Phase II Study of Venetoclax Added to Cladribine + Low Dose AraC (LDAC) Alternating with 5-Azacytidine Demonstrates High Rates of Minimal Residual Disease (MRD) Negative Complete Remissions (CR) and Excellent Tolerability in Older Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) ). https://doi.org/10.1056/NEJMoa2017699
Reviewed by Ulas Darda Bayraktar, MD on Dec 22, 2020

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.