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New Reference: Cabozantinib for metastatic papillary renal cell carcinoma

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New Reference: Cabozantinib for metastatic papillary renal cell carcinoma
Study:
  • Open label, randomized phase II trial (SWOG 1500)
  • Metastatic papillary renal cell Ca. No prior VEGF therapy
Efficacy:
  • Cabozantinib (n=44) vs. sunitinib (n=46) vs. crizotinib vs. savolitinib (latter two halted for futility)
  • Median PFS: 9.2 mos vs. 5.6 mos (HR: 0.61 [0.37-0.98])

J Clin Oncol 39, 2021 (suppl 6; abstr 270)

Pal SK, et al. Sunitinib versus cabozantinib, crizotinib or savolitinib in metastatic papillary renal cell carcinoma (pRCC): Results from the randomized phase II SWOG 1500 study.

https://doi.org/10.1200/JCO.2021.39.6_suppl.270

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