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New Reference: DD-MVAC vs. GC in muscle-invasive bladder cancer

New Reference: DD-MVAC vs. GC in muscle-invasive bladder cancer
Study:
  • Randomized phase II trial (GETUG-AFU V05 VESPER)
  • Nonmetastatic muscle-invasive bladder cancer
  • Dd-MVAC vs gemsitabin+cisplatin. Neoadjuvant OR adjuvant chemotherapy
Efficacy:
  • Organ confined response: 77% v 63% (p = 0.001)
  • Neoadjuvant cohort 3 year PFS: 69% v 58%, HR = 0.68 (p = 0.014)
Safety:
  • Grade >=3 AEs: 52% vs 55%
  • Severe anemia: dd-MVAC > Gem-Cis (P < .001)
  • Asthenia 14% vs 4.1% (P < .001)
  • Grade ≥ 3 GIS disorders: dd-MVAC arm> Gem-Cis (P = .003)

J Clin Oncol. 2022 Mar 7;JCO2102051.

Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin or Gemcitabine and Cisplatin as Perioperative Chemotherapy for Patients With Nonmetastatic Muscle-Invasive Bladder Cancer: Results of the GETUG-AFU V05 VESPER Trial

https://doi.org/10.1200/jco.21.02051

Reviewed by Hasan Cagri Yildirim, MD on Mar 28, 2022

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