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New Reference: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma

New Reference: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma
Study:
  • Phase 3, open label, randomized study (RELEVANCE)
  • Untreated grade 1-3a FL
  • R2 (n:513) or R-chemo (n:517), followed by rituximab maintenance
Efficacy:
  • ORR: 61% and 65%, CR/CRu: 48% and 53% (p: 0.10)
  • PFS did not differ HR= 1.03 [95% CI, 0.84 to 1.27], P = .78)
  • 6 year PFS: 60% (95% CI, 55 to 64) and 59% (95% CI, 54 to 64)
  • 6 year OS: 89% in both groups
Safety:
  • ≥ grade 5 TEAE: 9 patients and 6 patients
  • Second primary malignancies 57 (11%) patients and 67 (13%) patients

J Clin Oncol. 2022 Aug 10;JCO2200843.

Morschhauser F, Nastoupil L, Feugier P, et al. Six-Year Results From RELEVANCE: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma

https://doi.org/10.1200/jco.22.00843

Reviewed by Hasan Çağrı Yıldırım, MD on Aug 16, 2022

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