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New Reference:  Mirvetuximab soravtansine in platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression

New Reference:  Mirvetuximab soravtansine in platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression
Study:
  • A Phase III, Randomized, Open-label trial (MIRASOL)
  • Platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression
  • Mirvetuximab soravtansine (n=227) vs SOC (n=226)
Efficacy:
  • mPFS: 5.91 vs. 4.34 mos, HR:0.72, p=0.0082
  • mOS: 16.46 vs. 12.75 mos, HR: 0.67, p=0.0046
  • ORR: 36.1% vs.14.6%, p<0.0001
Safety:
  • Grade≥3: Keratopathy (9%vs.0), blurry vision (8% vs.0), neutropenia (1% vs.31%), thrombocytopenia (1% vs.27%).

Journal of Clin Oncol 2023 41:17_suppl, LBA5507-LBA5507

Kathleen N M et al. Phase III MIRASOL (GOG 3045/ENGOT-ov55) study: Initial report of mirvetuximab soravtansine vs. investigator’s choice of chemotherapy in platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression.

http://doi.org/10.1200/JCO.2023.41.17_suppl.LBA5507

Reviewed by Elvin CHALABİYEV, MD on JUL 10, 2023

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