Altai Protocol Library

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Kütüphanede Ara Ara

New Reference: Nivolumab + cabozantinib for previously untreated advanced clear cell renal cell carcinoma

New Reference: Nivolumab + cabozantinib for previously untreated advanced clear cell renal cell carcinoma
Study:
  • Randomized, open-label phase III trial (TIVO-3)
  • Previously untreated RCC with clear cell component
  • Cabozantinib 40 daily + nivolumab 240 q14 (n=323) vs. sunitinib 50 daily 4/6 wks (n=328), all until disease progression
Efficacy:
  • CR: 8.0% vs. 4.6%
  • ORR: 55.7% vs. 27.1% (p<0.001)
  • Median DoR: 20.2 mos [17.3-NE] vs. 11.5 mos [8.3-18.4]
  • Median PFS: 16.6 vs. 8.3 mos (HR: 0.51 [0.41-0.64])
  • OS @ 1yr: 85.7% vs. 75.6% mos (HR: 0.60 [0.40-0.89])
Safety:
  • Grade >=3 AEs: diarrhea (6.9% vs. 4.4%), PPE (7.5% vs. 7.5%), hypertension (12.5% vs. 13.1%), increased ALT (5.3% vs. 2.2%)

N Engl J Med 2021;384:829-41

Choueiri TK, et al. Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma

https://doi.org/10.1056/NEJMoa2026982

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Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

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