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New Reference: Overall Survival with Brentuximab Vedotin in Stage III or IV Hodgkin’s Lymphoma

New Reference: Overall Survival with Brentuximab Vedotin in Stage III or IV Hodgkin’s Lymphoma
Study:
  • Multicenter, randomized, open-label trial
  • Stage 3 or 4 advanced Hodgkin’s lymphoma
  • A+AVD (n:664) or ABVD (n:670)
Efficacy:
  • OS favored A+AVD over ABVD (HR: 0.59; P=0.009)
  • 6 year OS: 93.9% (95% CI, 91.6 to 95.5) vs 89.4% (95% CI, 86.6 to 91.7)
  • 6 year PFS: 82.3% and 74.5%, HR:0.68; 95% CI, 0.53 to 0.86)
Safety:
  • Completed all treatment: 89.3% vs 90.7%
  • Any cause related death: 39 vs 64 patients
  • Hodgkin Lymphoma related death: 32 vs 45 patients
  • Second cancer related death: 1 vs 11 patients

N Engl J Med. 2022 Jul 28;387(4):310-320.

Ansell SM, Radford J, Connors JM, et al. Overall Survival with Brentuximab Vedotin in Stage III or IV Hodgkin’s Lymphoma.

https://doi.org/10.1056/nejmoa2206125

Reviewed by Hasan Çağrı Yıldırım, MD on Aug 16, 2022

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