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New Reference: Paclitaxel and Carboplatin for uterine carcinosarcoma

New Reference: Paclitaxel and Carboplatin for uterine carcinosarcoma
  • International, randomized, open label, noninferiority phase III
  • Chemotherapy-naïve uterine or ovarian carcinosarcoma
  • CARBOplatin + PACLitaxel (n=228) or Ifosfamide + PACLitaxel (n=221) for 6-10 cycles
  • For UCS: mOS: 37 vs. 29 mos (HR=0.87 P < 0.01 for noninferiority)
  • mPFS: 16 vs 12 mos (HR = 0.73; P = < 0.01 for noninferiority)
  • Grade >=3 AEs: 82% vs 50%
  • Grade >=3 neurologic AEs: 12% and 7% (P > .10)

J Clin Oncol. 2022 Mar 1;40(7):719-728.

Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial

Reviewed by Hasan Cagri Yildirim, MD on Mar 28, 2022

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