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New Reference: Pembrolizumab as adjuvant therapy in completely resected stage IIB or IIC melanoma 

New Reference: Pembrolizumab as adjuvant therapy in completely resected stage IIB or IIC melanoma 
Study:
  • Double-blind, randomised, phase 3 study (KEYNOTE-716)
  • Newly diagnosed, completely resected stage IIB or IIC melanoma
  • Pembrolizumab (n=483) or placebo (n=486)
Efficacy:
  • RFS @ 20.9 mos: 85% vs. 76% [ HR: 0.61 (0·45–0·82)]
  • mRFS not reached
Safety:
  • Grade >= 3 AEs: 16% vs 4%
  • AEs related death: 0 vs 4 patients

Lancet. 2022 Apr 30;399(10336):1718-1729.

Luke, Jason J et al. “Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial

https://doi.org/10.1016/s0140-6736(22)00562-1

Reviewed by Hasan Çağrı Yıldırım, MD on May 30, 2022

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