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New Reference: Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma

New Reference: Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma
Study:
  • Phase II, open-label, multicenter, multicohort study
  • The patient had to have experienced relapse or be ineligible for ASCT
  • Pembrolizumab (n=53)
Efficacy:
  • cORR: 41.5% [22 of 53 pts]
  • CR: 20.8% [ 11of 53 pts]
  • mDoR: NR [NR-NR]
  • median PFS: 4.3 mos
Safety:
  • Grade≥3: Neutropenia (13.2%), astenia (1.9%), AST increased (1.9%)

BLOOD, VOL 142, ISSUE 2, P141-145, JUL 2023

Zinzani Pier Luigi et al. Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma: final analysis of KEYNOTE-170

http://doi.org/10.1182/blood.2022019340

Reviewed by Elvin CHALABİYEV, MD on AUG 10, 2023

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