1. Home /
    2. Altai Protocol Library /
  2. New Reference: Ribociclib plus Letrozole in Advanced Breast Cancer

Altai Protocol Library

1041 protocols and counting

All protocols with references and links

All protocols reviewed by a Medical Oncologist/Hematologist

All protocols in major guidelines included

Ability to create your own protocols

Search Library Posts Search
Altai Protocol Library

New Reference: Ribociclib plus Letrozole in Advanced Breast Cancer

New Reference: Ribociclib plus Letrozole in Advanced Breast Cancer
Study:
  • Randomized phase III trial (MONALEESA-2)
  • Postmenopausal, HR-positive, HER2-negative recurrent or metastatic breast cancer with no previous systemic therapy for advanced disease
  • Ribociclib or placebo in combination with letrozole
Efficacy:
  • mOS: 63.9 vs 51.4 mos (HR:0.76; P=0.008)
Safety:
  • Grade >=3 neutropenia: 63.8% vs 1.2%
  • Grade >=3 hepatobiliary AEs: 14.4% vs 4.8%
  • Prolonged QT: 4.5% vs2.1%

N Engl J Med. 2022 Mar 10;386(10):942-950.

Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer

https://doi.org/10.1056/nejmoa2114663

Reviewed by Hasan Cagri Yildirim, MD on Mar 28, 2022

Altai Chemo Planner

Quickly Prepare Accurate Chemotherapy Orders

Altai Chemo Planner employs Altai Protocol Library that includes over 1000 chemotherapy protocols for both Hematology and Oncology. You can find major guidelines' protocols, parenteral, and oral, in the library. Altai Protocol Library is frequently and regularly updated.

Learn More